c-Jun (pS63) Mouse, Unlabeled, Clone: 2/C-JUN (PS63), BD

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 558036

Catalog No. BDB558036

Description

The activator protein transcription factor (AP-1) was identified as a protein that recognizes specific sequences in the cis-control regions of the SV40 virus and the human metallothionein IIA gene. AP-1 is composed of protein products of two different gene families: jun and fos. The AP-1 transcription factor is either a homodimer of Jun proteins or a heterodimer of Jun and Fos proteins. The transcriptional activity of Jun is enhanced by phosphorylation of serines 63 (S63) and 73 in its activation domain. Phosphorylation at both sites is necessary for stimulating the activating function of Jun. Jun is phosphorylated by JNK protein kinases that are activated by the same signals that potentiate Jun activity. The 2/c-Jun/(S63) monoclonal antibody recognizes the phosphorylated S63 of c-Jun.

Host Species: Mouse
Clone: 2
Isotype: IgG1
Species Reactivity: Human

Immunohistochemistry (Formalin-Antigen Retrieval Required), Western Blotting

Specifications

• Antigen: c-Jun (pS63)
• Classification: Monoclonal
• Concentration: 0.25mg/mL
• Formulation: Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
• Immunogen: Phosphorylated Human c-Jun
• Quantity: 0.1 mg
• Research Discipline: Cell Biology
• Target Species: Human, Mouse, Rat
• Isotype: IgG1

• Applications: Western Blot
• Clone: 2/C-JUN (PS63)
• Conjugate: Unconjugated
• Host Species: Mouse
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at -20°C.

For Research Use Only.