MilliporeSigma™ anti-c-K-Ras Clone: 234-4.2,

Catalog No.	Quantity	Conjugate
OP24100UG	100 μg	Unconjugated

Catalog No. OP24100UG Supplier MilliporeSigma™ Supplier No. OP24100UG

Description

Mouse Monoclonal Antibody

Specifically detects c-K-Ras Clone: 234-4.2 in Human, Mouse, Rat samples, and it is validated for Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Immuno Blotting

The human ras gene family consists of three identified members, H, K and N-ras, encoding proteins of 188-189 amino acids and 21,000 (p21) molecular weight. Human H- and K-ras are the homologues of v-H- and v-K-ras sequences originally isolated from Harvey and Kirsten strains of rat sarcoma viruses. Normal human cellular ras genes can be activated to oncogenes by mutations occurring in codons 12, 13 and 61; such mutated, activated and transforming ras genes have been identified and isolated from human tumors and cultured tumor cells. Although the expression patterns of Ras proteins in normal human tissues are known, similar information for activated ras oncogene encoded p21s and their relevance to human disease diagnosis and prognosis is still emerging. K-ras mutations have been identified in several cancers to date including lung and colorectal tumors.

Specifications

• Antigen: c-K-Ras
• Applications: Immunoblot, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation
• Classification: Monoclonal
• Clone: 234-4.2
• Conjugate: Unconjugated
• Formulation: In 50mM sodium phosphate buffer, 0.2% gelatin, pH 7.5.
• Host Species: Mouse
• Immunogen: recombinant, rat K-Ras
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Test Specificity: Recognizes c-K-Ras and v-K-Ras in SW480 and Y1 cells and normal skin tissue. Cross-reacts with c-H-Ras and c-N-Ras.
• Target Species: Human, Mouse, Rat
• Content And Storage: 2°C to 8°C
• Form: Purified
• Isotype: IgG2a

For Research Use Only