c-Myc with control Mouse anti-Human, Unlabeled, Clone: 9E10., BD

Catalog No.	Quantity
BDB551102	150 μg
BDB551101	50 μg

Catalog No. BDB551102 Supplier BD Biosciences Supplier No. 551102

Description

Mouse Monoclonal Antibody

The myc gene family contains at least seven closely related genes, c-myc, N-myc, L-myc, P-myc, R-myc, S-myc, and B-myc. C-myc plays a role in proliferation, transformation, and differentiation. It is expressed during embryonic development, in a wide variety of adult tissues, and is amplified in many tumors, particularly lung, breast, cervical and colon carcinomas. Cellular localization has been described as nuclear and/or cytopasmic. C-myc has three sequence motifs in the carboxy terminus, a leucine zipper, a helix-loop-helix, and a basic region. It forms sequence-specific (CACGTG) DNA binding heterodimers with max, a helixloop-helix/leucine zipper protein. Both the leucine zipper domain and the helixloop-helix motif of c-myc contribute to heterodimer formation. DNA binding of myc-max dimers results in a conformational change of the DNA and transcriptional activation. C-myc migrates at 62 kDa in SDS-PAGE. Clone 9E10 recognizes human c-myc. A synthetic peptide corresponding to a C-terminal epitope of the human c-myc protein (AEEQKLISEEDL) was used as an immunogen.

Specifications

• Antigen: c-Myc with control
• Applications: Western Blot
• Classification: Monoclonal
• Clone: 9E10.
• Conjugate: Unconjugated
• Host Species: Mouse
• Purification Method: Affinity Purified
• Quantity: 150 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Includes: Purified Mouse Anti-Human c-Myc (150μg) 3vials of 50μg; Jurkat Cell Lysate (50μg)
• Target Species: Human
• Content And Storage: Store undiluted at -20°C.
• Isotype: IgG1

Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov

For Research Use Only.