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Description
This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. A single, unique beta-chain encoded by this gene assembles with seven identical alpha-chains into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. C4b-binding protein has a regulatory role in the coagulation system also, mediated through the beta-chain binding of protein S, a vitamin K-dependent protein that serves as a cofactor of activated protein C. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Alternative splicing gives rise to multiple transcript variants. [provided by RefSeq
Specifications
Specifications
| Antigen | C4BPB |
| Applications | ELISA, Immunoprecipitation, Western Blot |
| Classification | Monoclonal |
| Clone | 1G9 |
| Conjugate | Unconjugated |
| Description | Mouse monoclonal antibody raised against a full-length recombinant C4BPB. |
| Formulation | PBS with no preservative; pH 7.4 |
| Gene | C4BPB |
| Gene Accession No. | BC005378 |
| Gene Alias | C4BP |
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