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Invitrogen™ Complement C9 Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA529066
Description
Recommended positive controls: Jurkat. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
C5b-9 membrane attack complexes are assembled from five precursor molecules in the serum. Proteolytic cleavage of C5 by C5 convertase generates C5b which initiates assembly of the C5b-9 complex. The last step of C5b-9 complex formation involves polymerization of C9 which accompanies insertion of the complex into the cell membrane. During formation of C5b-8 and C9 polymerization, neoantigens are generated which are unique to the C5b-9 complex and are not present on any of the individual native complex components. The complement regulatory proteins CD59 and complement S-protein can both prevent C5b-9 insertion into the cell membrane. The formed SC5b-9 complex is unable to attach to cells and is cytolytically inactive. C5b-9 is involved in the progression of chronic proteinuric renal disease by mediating continuous tubulointerstitial damage. Early tubulointerstitial injury in the remnant kidney can be improved when C5b-9 complex forming is abrogated.
Specifications
Complement C9 | |
Polyclonal | |
Unconjugated | |
C9 | |
ARMD15; C9; C9D; complement C9; complement component 9; complement component C9; Complement component C9a; Complement component C9b; complement protein C9; complement protein C9 precursor | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
735 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Immunohistochemistry (Paraffin), Western Blot | |
1 mg/mL | |
PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7 | |
P02748 | |
C9 | |
Recombinant fragment corresponding to a region within amino acids 153 and 429 of Human C9. | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |
Safety and Handling
WARNING: Cancer - www.P65Warnings.ca.gov
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