MilliporeSigma™ anti-Calcitonin Gene Related Peptide (CGRP), Polyclonal

Rabbit Polyclonal Antibody

Supplier:  MilliporeSigma™ PC205L100UL

Catalog No. PC205L100UL

Description

Specifically detects Calcitonin Gene Related Peptide (CGRP) Clone: in Mouse, Rat samples, and it is validated for Immunofluorescence, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin)

Neurotransmitters can be defined as chemical substances that are released by the presynaptic neuron before being bound by receptors on the postsynaptic cell surface. It has been well established that the nervous system utilizes neurotransmitters for cell signaling. Neurotransmitters can be divided into two groups; low molecular weight transmitter molecules such as biogenic amines, purines, or amino acids, and bioactive peptides, of which more than 50 members have been identified in the mammalian central nervous system. Many low molecular weight neurotransmitters are produced within the axon terminal from common cellular metabolites and packaged into synaptic vesicles. In contrast, neuropeptides are synthesized in the cell body and packaged into large dense core vesicles for delivery to the presynaptic membrane. The transport and delivery of vesicles containing neurotransmitter is a highly regulated and complex process. The calcitonin gene peptide superfamily consists of calcitonin, calcitonin gene-related peptide (CGRP), amylin, and adrenomedullin. CGRP is a 37 amino acid neuropeptide that shows widespread distribution and acts as a potent vasodilator. The immunolocalization, neuronal distribution, and vesicular compartmentalization of neurotransmitter molecules and their precursors are important for understanding the modulation, regulation, and function of neurotransmitters in the nervous system.

Specifications

• Antigen: Calcitonin Gene Related Peptide (CGRP)
• Classification: Polyclonal
• Formulation: Undiluted serum.
• Immunogen: rat, alpha;-calcitonin gene related peptide (α-CGRP)
• Regulatory Status: RUO
• Test Specificity: Recognizes theα-calcitonin gene related peptide in rat amygdala and spinal cord.
• Content And Storage: −20°C
• Isotype: IgG

• Applications: Immunofluorescence, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin)
• Conjugate: Unconjugated
• Host Species: Rabbit
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Mouse, Rat
• Form: Undiluted

For Research Use Only