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MilliporeSigma™ anti-Calreticulin (405-417), Polyclonal

Catalog No. 20891050UL Shop All MilliporeSigma Products
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50 μL
Conjugate:
Unconjugated
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20-891-050UL 50 μL Unconjugated
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Catalog No. 20-891-050UL Supplier MilliporeSigma™ Supplier No. 20891050UL
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Description

Rabbit Polyclonal Antibody

Specifically detects Calreticulin (405-417) Clone: in Bovine, Canine, Hamster, Human, Monkey, Mouse, Porcine, Rat samples, and it is validated for Immunocytochemistry, Immunohistochemistry, Immunoprecipitation

Calreticulin is a calcium binding protein found primarily in the ER and the sarcoplasmic reticulum, although it also has been detected in the nucleus and nuclear envelope. It has the conserved KDEL sequence at its C-terminus for retention in the ER. Calreticulin, which contains both high and low affinity calcium binding sites, is involved in calcium storage and regulation. The calcium binding at the C-terminus of calreticulin has been postulated to be involved with regulating the interaction of KDEL proteins with the KDEL receptor. Calreticulin also acts as a molecular chaperone for protein folding, in concert with Grp78 and Grp94.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Calreticulin (405-417)
Applications Immunocytochemistry, Immunohistochemistry, Immunoprecipitation
Classification Polyclonal
Conjugate Unconjugated
Formulation In PBS, 50% glycerol, pH 7.2.
Host Species Rabbit
Immunogen a synthetic peptide [(C)EEEDVPGQAKDEL] corresponding to amino acids 405-417 of human calreticulin, conjugated to KLH
Quantity 50 μL
Regulatory Status RUO
Primary or Secondary Primary
Test Specificity Recognizes the ∽63kDa calreticulin protein in heat-shocked HeLa cells.
Target Species Bovine, Canine, Hamster, Human, Monkey, Mouse, Pig, Rat
Content And Storage −20°C
Form Purified
Isotype IgG
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For Research Use Only

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