CaMKI Rabbit anti-Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA1543

Catalog No. PA1543

Description

PA1-543 detects calciµm/calmodulin-dependent kinase I (CaMKI) from rat and mouse brain extract. PA1-543 has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~43 kDa protein representing CaMKI from rat and mouse brain extract. PA1-543 immunizing peptide corresponds to amino acid residues 1-18 from human CaMKI protein. PA1-543 immunizing peptide (Cat. No. PEP-134) is available for use in neutralization and control experiments.

Calcium/calmodulin-dependent kinases (CaMKs) are a subfamily of the serine/threonine protein kinase family that includes CaMKI, CaMKII, and CaMKIV. There have been identified multiple substrates for CaMKI, including synapsin 1, synapsin 2, CREB, and CFTR, and its activation is dependent upon phosphorylation of Thr177 by CaMK kinase (CaMKK). Studies suggest that CaMKI plays an important role in retinal function and its expression is regulated by light stimulation.

Specifications

• Antigen: CaMKI
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CAMK1
• Format: Liquid
• Gene Symbols: CAMK1
• Immunogen: Synthetic Peptide: A(1) V E G P R W K Q A E D I R D I Y D(18)
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Type: Antibody
• Monoclonal or Polyclonal: Polyclonal
• Target Species: Mouse, Rat

• Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 1mg/mL BSA and 0.05% sodium azide
• Gene Accession No.: Q14012, Q91YS8, Q63450
• Gene Alias: CaMKI, Calcium / calmodulin dependent protein kinase 1, CAMK1-PEN
• Host Species: Rabbit
• Isotype: IgG
• Quantity: 100 μg
• Storage Requirements: -20° C, Avoid Freeze/Thaw Cycles
• Primary or Secondary: Primary
• Gene ID (Entrez): 171503, 52163, 8536