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CaM Kinase II Mouse, Unlabeled, Clone: 45, BD

Catalog No. BDB611292 Shop All BD Biosciences Products
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BDB611293 150 μg
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Catalog No. BDB611292 Supplier BD Biosciences Supplier No. 611292
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Description

Mouse Monoclonal Antibody

Ca2+;/calmodulin-dependent protein kinase II (CaM kinase II) is a multifunctional Ser/Thr kinase that regulates a number of cellular functions in response to increased intracellular Ca2+;. CaM kinase II is widely distributed, but is predominantly expressed in brain. It is involved in the regulation of neuronal functions such as neurotransmitter synthesis, neurotransmitter release, long-term potentiation, and formation of spatial learning. Neuronal CaM kinase II contains heteromers of two major subunits, α and β, at a ratio of 2:1 and homomers of α subunits. Each subunit has N-terminal ATP-binding and catalytic/regulatory domains and a C-terminal association domain. The regulatory domain consists of the autoinhibitory and calmodulin-binding sites. Assembly of the association domains of multiple subunits positions the regulatory domains for intersubunit autophosphorylation. After binding Ca2+;/calmodulin, CaM kinase II undergoes rapid autophosphorylation of the α and β subunits, which results in a substantial increase in its affinity for Ca2+;/calmodulin.

Host Species: Mouse
Clone: 45
Isotype: IgG1
Species Reactivity: Rat
Immunogen: Rat CaM Kinase IIα aa. 448-460
Formula Weight [Chemical]: 52kDa

Immunofluorescence, Immunohistochemistry, Western Blotting

TRUSTED_SUSTAINABILITY

Specifications

Antigen CaM Kinase II
Applications In vitro Assay, Western Blot
Classification Monoclonal
Clone 45
Concentration 250μg/mL
Conjugate Unconjugated
Description Ca2+/calmodulin-dependent protein kinase II
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Rat CaM Kinase IIα aa. 448-460
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Canine, Human, Mouse, Rat
Content And Storage Store undiluted at -20°C.
Isotype IgG1
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Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov

For Research Use Only.

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