CaM Kinase II Mouse, Unlabeled, Clone: 45, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 611292
Ca2+;/calmodulin-dependent protein kinase II (CaM kinase II) is a multifunctional Ser/Thr kinase that regulates a number of cellular functions in response to increased intracellular Ca2+;. CaM kinase II is widely distributed, but is predominantly expressed in brain. It is involved in the regulation of neuronal functions such as neurotransmitter synthesis, neurotransmitter release, long-term potentiation, and formation of spatial learning. Neuronal CaM kinase II contains heteromers of two major subunits, α and β, at a ratio of 2:1 and homomers of α subunits. Each subunit has N-terminal ATP-binding and catalytic/regulatory domains and a C-terminal association domain. The regulatory domain consists of the autoinhibitory and calmodulin-binding sites. Assembly of the association domains of multiple subunits positions the regulatory domains for intersubunit autophosphorylation. After binding Ca2+;/calmodulin, CaM kinase II undergoes rapid autophosphorylation of the α and β subunits, which results in a substantial increase in its affinity for Ca2+;/calmodulin.
Host Species: Mouse
Species Reactivity: Rat
Immunogen: Rat CaM Kinase IIα aa. 448-460
Formula Weight [Chemical]: 52kDa
Immunofluorescence, Immunohistochemistry, Western Blotting
|CaM Kinase II|
|Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.|
|Store undiluted at -20°C.|
|In vitro Assay, Western Blot|
|Ca2+/calmodulin-dependent protein kinase II|
|Rat CaM Kinase IIα aa. 448-460|
|Canine, Human, Murine, Rat|
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