CaM Kinase II Mouse, Unlabeled, Clone: 45, BD

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 611293

Catalog No. BDB611293

Description

Ca²⁺;/calmodulin-dependent protein kinase II (CaM kinase II) is a multifunctional Ser/Thr kinase that regulates a number of cellular functions in response to increased intracellular Ca²⁺;. CaM kinase II is widely distributed, but is predominantly expressed in brain. It is involved in the regulation of neuronal functions such as neurotransmitter synthesis, neurotransmitter release, long-term potentiation, and formation of spatial learning. Neuronal CaM kinase II contains heteromers of two major subunits, α and β, at a ratio of 2:1 and homomers of α subunits. Each subunit has N-terminal ATP-binding and catalytic/regulatory domains and a C-terminal association domain. The regulatory domain consists of the autoinhibitory and calmodulin-binding sites. Assembly of the association domains of multiple subunits positions the regulatory domains for intersubunit autophosphorylation. After binding Ca²⁺;/calmodulin, CaM kinase II undergoes rapid autophosphorylation of the α and β subunits, which results in a substantial increase in its affinity for Ca²⁺;/calmodulin.

Host Species: Mouse
Clone: 45
Isotype: IgG1
Species Reactivity: Rat
Immunogen: Rat CaM Kinase IIα aa. 448-460
Formula Weight [Chemical]: 52kDa

Immunofluorescence, Immunohistochemistry, Western Blotting

Specifications

• Antigen: CaM Kinase II
• Classification: Monoclonal
• Concentration: 250μg/mL
• Description: Ca2+/calmodulin-dependent protein kinase II
• Host Species: Mouse
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at -20°C.

• Applications: In vitro Assay, Western Blot
• Clone: 45
• Conjugate: Unconjugated
• Formulation: Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
• Immunogen: Rat CaM Kinase IIα aa. 448-460
• Quantity: 150 μg
• Research Discipline: Cell Biology
• Target Species: Canine, Human, Mouse, Rat
• Isotype: IgG1

Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov

For Research Use Only.