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CaM Kinase IV Mouse, Unlabeled, Clone: 26, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 610276

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Catalog No. BDB610276

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CaM-kinase IV (Ca2+calmodulin-dependent protein kinase IV, also described as CaM-kinase Gr) is activated through the binding of Ca2+/CaM and by phosphorylation. This kinase has high sequence homologies with the catalytic and regulatory domains of CaM-kinase II. CaM-kinase IV is a monomer which is highly expressed in cerebellum, thymus, and testis. Its subcellular distrubution includes localization in both the synaptic regions of the molecular layer of the cerebellum, and the nuclei of cerebellar granule cells. CaM-kinase IV has an autoinhibitory domain within residues 305-321 that can suppress kinase activity in the absence of Ca2+/CaM. This type of domain is common in many other CaM-dependent kinases and phosphatases. CaM-kinase IV does not appear to be significantly activated by autophosphorylation but it can be activated approximately 5-10-fold when phosphorylated by CaM-kinase IV kinase.

Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting



CaM Kinase IV
Affinity Purified
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Cell Biology
Human, Murine, Rat
Western Blot
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Store undiluted at -20°C.
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