CEA, clone: 1105, Invitrogen™

Mouse Monoclonal Antibody

Supplier:  Thermo Scientific MA514674

Catalog No. PIMA514674

Description

This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of all variants has not been defined.

The predicted MW of CEA is ∽77kD, but by Western blot MA5-14674 detects CEA with varying degrees of glycosylation at ∽77-180kD. Product MA514674 is a smaller package size of MIC0101 (formerly sold as a Seradyn product).

Specifications

• Antigen: CEA
• Classification: Monoclonal
• Concentration: 1mg/mL
• Gene: CEACAM5
• Gene Alias: meconium antigen 100, Carcinoembryonic Antigen, CD66e
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 1048
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Radioimmune Assays (RIA), Western Blot
• Clone: 1105
• Conjugate: Unconjugated
• Gene Accession No.: P06731
• Gene Symbols: CEACAM5
• Immunogen: Purified CEA from pooled tumors
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1