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  6. Casein Kinase IIα/α Mouse, Unlabeled, Clone: 31, BD

Casein Kinase IIα/α Mouse, Unlabeled, Clone: 31, BD

Catalog No. BDB611610 Shop All BD Biosciences Products
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BDB611611 150 μg
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Catalog No. BDB611610 Supplier BD Biosciences Supplier No. 611610

Description

Mouse Monoclonal Antibody

Casein kinase II (CKII, CK2) is a pleiotropic, ubiquitous, and constitutively active Ser/Thr kinase that utilizes both ATP and GTP as phosphoryl donors to catalyze the phosphorylation of numerous protein substrates. It has been implicated in DNA replication, control of metabolism, and regulation of transcription and translation. CKII is a messenger independent kinase due to the fact that its activity is not affected by factors that regulate other protein kinases (e.g. cAMP, Ca2+, diacylglycerol). It is composed of two catalytic (α and α′) subunits and two regulatory (β) subunits. The β subunits stabilize the holoenzyme and enhance the activity of the α subunits. Although the enzyme exists as a tetramer, the free α/α′ subunits are catalytically active by themselves and are present in cells under some conditions. The α and α′ subunits (85% homologous) are encoded by distinct genes and have been detected in multiple species including human, bovine, and avian. CKII is found primarily in the nucleus in dividing cells, but can be detected in the cytoplasm in quiescent cells. Thus, CKII activity is required for cell cycle progression and other essential signal transduction events.

Host Species: Mouse
Clone: 31
Isotype: IgG1
Species Reactivity [for Features Main]: Rat
Immunogen: Rat Casein Kinase II α aa. 1-123

Immunofluorescence, Western Blotting

TRUSTED_SUSTAINABILITY

Specifications

Antigen Casein Kinase IIα/α
Applications Western Blot
Classification Monoclonal
Clone 31
Concentration 250μg/mL
Conjugate Unconjugated
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Rat Casein Kinase II α aa. 1-123
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Human, Mouse, Rat
Content And Storage Store undiluted at -20°C.
Isotype IgG1
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For Research Use Only.

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