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MilliporeSigma™ anti-Caspase 8 (MACH1; FLICE); Polyclonal; ™ (Chemicon™) Non-distribution product as customer accommodation.

Manufacturer:  MilliporeSigma™ AB1879/DEL

Catalog No. 50-173-292

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Description

Description

Apoptosis occurs during normal cellular development and involves dramatic changes in cellular structure. Disruption of apoptosis may contribute to cancer as well as other autoimmune diseases. Caspase family of cysteine proteases has been shown to play a key role in apoptosis. Caspase-8 is a 55kDa cytosolic protein that is synthesized as an inactive proenzyme. Activation of caspase-8 involves a two-step proteolysis: the cleavage of caspase-8 to generate a 43kDa fragment and a 12kDa which is further processed to 10kDa, and then the p43 is then cleaved to yield p26 and the release of the active site containing p18.

Western Blotting

Abbreviations: AP=Affinity Purification, ChIP=Chromatin IP, CM=Confocal Microscopy, DB=Dot Blot, EIA=ELISA, EM=Electron Microscopy, FC=Flow Cytometry, GS=Gel Supershift, IC=Immunocytochemistry, IF=Immunofluorescence, IH=Immunohistology/Immunohistochemistry, IP=Immunoprecipitation, IPK=IP Kinase Assay, KA=Kinase Assay, NEUT=Neutralization, PIA=Peptide Inhibition Assay, RIA=Radioimmunossay, TCA=T Cell Activation, WB=Western Blotting, Species: Am=Amphibian, Av=Avian, B=Bovine, Ca=Cat ,Ck=Chicken, D=Dog, Dr=Deer, Ds=Drosophila, El=Elk, Fg=Frog, Fs=Fish, Ft=Ferret, G=Goat, Gp=Guinea Pig, H=Horse, Hm=Hamster, Hu=Human, K=Kangaroo, Ms=Mouse, Nhp=Non-Human Primate, O=Ovine, P=Porcine, Rb=Rabbit, Rp=Reptile, Rt=Rat, Ys=Yeast, Xn=Xenopus, (wk)=cross reacts weakly

Specifications

Specifications

Caspase 8/MACH1/FLICE
Affinity Purified
recombinant, full lenGh, purified human Dspase 8
RUO
Primary
Bovine, Human, Monkey, Murine, Rat
Unconjugated
Rabbit
50μg
Apoptosis, Endocrine/Metabolism
Polyclonal
Documents
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