MilliporeSigma™ anti-Caspase 8 (MACH1; FLICE); Polyclonal; ™ (Chemicon™)

Supplier:  MilliporeSigma™ AB1879/DEL

Catalog No. 50-173-292

Description

Apoptosis occurs during normal cellular development and involves dramatic changes in cellular structure. Disruption of apoptosis may contribute to cancer as well as other autoimmune diseases. Caspase family of cysteine proteases has been shown to play a key role in apoptosis. Caspase-8 is a 55kDa cytosolic protein that is synthesized as an inactive proenzyme. Activation of caspase-8 involves a two-step proteolysis: the cleavage of caspase-8 to generate a 43kDa fragment and a 12kDa which is further processed to 10kDa, and then the p43 is then cleaved to yield p26 and the release of the active site containing p18.

Western Blotting

Specifications

• Antigen: Caspase 8/MACH1/FLICE
• Conjugate: Unconjugated
• Immunogen: recombinant, full lenGh, purified human Dspase 8
• Quantity: 50 μg
• Research Discipline: Apoptosis, Endocrine/Metabolism
• Target Species: Bovine, Human, Monkey, Mouse, Rat

• Classification: Polyclonal
• Host Species: Rabbit
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary