γ-Catenin Mouse, Unlabeled, Clone: 15, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 610253
γ-Catenin (plakoglobin) was identified as a compenent of desmosomes where it associates with desmoglein. γ-Catenin and β-Catenin are closely related proteins that have significant homology with the Drosophila armadillo protein. In addition to complexing with E-Cadherin, γ-Catenin and β-Catenin have been observed in association with the intracellular domain of N-Cadherin. It has been proposed that one molecule of α-Catenin and at least one molecule of β-Catenin and γ-Catenin simultaneously bind to a single cadherin molecule. A 19 amino acid sequence of desmoglein (Dsg1) was found to be critical for binding of γ-Catenin. This region has significant homology to the catenin-binding domain of classical cadherins, thus suggesting a common mechanism for γ-Catenin localization at both adherens junctions and desmosomes.
Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting
|Human γ-Catenin aa. 553-738|
|Canine, Chicken, Human, Murine, Rat|
|Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.|
|Store undiluted at -20°C.|
We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.
Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.Ok
For Research Use Only.