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γ-Catenin Mouse, Unlabeled, Clone: 15, BD
Mouse Monoclonal Antibody
Supplier: BD Biosciences 610254
Description
γ-Catenin (plakoglobin) was identified as a compenent of desmosomes where it associates with desmoglein. γ-Catenin and β-Catenin are closely related proteins that have significant homology with the Drosophila armadillo protein. In addition to complexing with E-Cadherin, γ-Catenin and β-Catenin have been observed in association with the intracellular domain of N-Cadherin. It has been proposed that one molecule of α-Catenin and at least one molecule of β-Catenin and γ-Catenin simultaneously bind to a single cadherin molecule. A 19 amino acid sequence of desmoglein (Dsg1) was found to be critical for binding of γ-Catenin. This region has significant homology to the catenin-binding domain of classical cadherins, thus suggesting a common mechanism for γ-Catenin localization at both adherens junctions and desmosomes.
Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting

Specifications
γ-Catenin | |
Monoclonal | |
250μg/mL | |
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
Human γ-Catenin aa. 553-738 | |
150 μg | |
Cell Biology | |
Canine, Chicken, Human, Mouse, Rat | |
IgG2a |
Western Blot | |
15 | |
Unconjugated | |
Mouse | |
Affinity Purified | |
RUO | |
Primary | |
Store undiluted at -20°C. |
Safety and Handling
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For Research Use Only.