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γ-Catenin Mouse, Unlabeled, Clone: 15, BD

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 610254

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Catalog No. BDB610254


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Description

Description

γ-Catenin (plakoglobin) was identified as a compenent of desmosomes where it associates with desmoglein. γ-Catenin and β-Catenin are closely related proteins that have significant homology with the Drosophila armadillo protein. In addition to complexing with E-Cadherin, γ-Catenin and β-Catenin have been observed in association with the intracellular domain of N-Cadherin. It has been proposed that one molecule of α-Catenin and at least one molecule of β-Catenin and γ-Catenin simultaneously bind to a single cadherin molecule. A 19 amino acid sequence of desmoglein (Dsg1) was found to be critical for binding of γ-Catenin. This region has significant homology to the catenin-binding domain of classical cadherins, thus suggesting a common mechanism for γ-Catenin localization at both adherens junctions and desmosomes.

Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting

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Specifications

Specifications

γ-Catenin
Monoclonal
250μg/mL
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Human γ-Catenin aa. 553-738
150 μg
Cell Biology
Canine, Chicken, Human, Mouse, Rat
IgG2a
Western Blot
15
Unconjugated
Mouse
Affinity Purified
RUO
Primary
Store undiluted at -20°C.
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