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MilliporeSigma™ anti-Cathepsin B, Polyclonal

Rabbit Polyclonal Antibody

Manufacturer:  MilliporeSigma™ PC41100UG

Catalog No. PC41100UG


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Description

Description

Specifically detects Cathepsin B Clone: in Human samples, and it is validated for Immunohistochemistry (Paraffin)

Cathepsin B (CB) is a normal lysosomal proteinase which is expressed in all cells. It is a cysteine endoproteinase which is structurally and functionally related to the papain family of proteinases. CB is synthesized as an inactive~43kDa pro-enzyme which, by removal of a 62 amino acid propeptide, is activated to the single-chain form of~31kDa or the two-chain form (~25 and~5kDa subunits). Mature CB is normally localized in the lysosomes where it functions in protein turnover. It has also been shown to be capable of degrading extracellular matrix proteins at acidic and neutral pH. Endogenous inhibitors of cysteine proteinases, the cystatins and stefins, may play a major role in regulating their activity. In tumor cells and in cells exposed to mitogens, CB displays altered cellular trafficking resulting in the secretion of the~43kDa precursor. Elevated levels of CB correlate with malignancy suggesting that this enzyme may be a useful prognostic marker for several types of human cancers.
Specifications

Specifications

Cathepsin B
Unconjugated
purified
purified human liver cathepsin B
100μg
2°C to 8°C
Polyclonal
Human
Immunohistochemistry (Paraffin)
In 0.05M sodium phosphate buffer, 0.2% gelatin.
Rabbit
IgG
RUO
Primary
Recognizes the ∽43kDa latent and the ∽31kDa active forms of cathepsin B in breast carcinoma tissues.
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