MilliporeSigma™ anti-Cathepsin D Clone: BC011,

Catalog No.	Quantity	Conjugate
IM03100UG	100 μg	Unconjugated

Catalog No. IM03100UG Supplier MilliporeSigma™ Supplier No. IM03100UG

Description

Mouse Monoclonal Antibody

Specifically detects Cathepsin D Clone: BC011 in Human samples, and it is validated for Immunohistochemistry (Paraffin)

Cathepsin D is a normal lysosomal proteinase which is expressed in all cells. It is an aspartyl proteinase with a pH optimum in the range of 3-5 and contains two N-linked oligosaccharides. Cathepsin D is synthesized as an inactive 52kDa pro-enzyme. Activation involves the proteolytic removal of the 43 amino acid pro-fragment and internal cleavage to generate the two chain form made up of 34 and 14kDa subunits. Cathepsin D contains the mannose-6-phosphate lysosomal localization signal which targets the enzyme to the lysosomal compartment where it functions in the normal degradation of proteins. In certain tumor cells, cathepsin D is abnormally processed and is secreted in its 52kDa precursor form. Numerous clinical studies as well as in vitro evidence suggest that cathepsin D plays an important role in malignant transformation and may be a useful prognostic indicator for breast cancer.

Specifications

• Antigen: Cathepsin D
• Applications: Immunohistochemistry (Paraffin)
• Classification: Monoclonal
• Clone: BC011
• Conjugate: Unconjugated
• Formulation: In 50mM sodium phosphate buffer, 0.2% gelatin, pH 7.5.
• Host Species: Mouse
• Immunogen: mature, human cathepsin D
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Test Specificity: Recognizes the ∽52kDa latent form, the ∽48kDa mature form, and the ∽34kDa subunit of cathepsin D in breast carcinoma tissue extracts.
• Target Species: Human
• Content And Storage: 2°C to 8°C
• Form: Purified
• Isotype: IgG2a

For Research Use Only