CBL, Mouse, Clone: 6D12, Abnova
Mouse monoclonal antibody raised against a partial recombinant CBL.
Manufacturer: Abnova Corporation H00000867M01C
The cbl oncogene was first identified as part of a transforming retrovirus which induces mouse pre-B and pro-B cell lymphomas. As an adaptor protein for receptor protein-tyrosine kinases, it positively regulates receptor protein-tyrosine kinase ubiquitination in a manner dependent upon its variant SH2 and RING finger domains. Ubiquitination of receptor protein-tyrosine kinases terminates signaling by marking active receptors for degradation. [provided by RefSeqSequence: NIQSQAPSITESSTFGEGNLAAAHANTGPEESENEDDGYDVPKPPVPAVLARRTLSDISNASSSFGWLSLDGDPTTNVTEGSQVPERPPKPFPRRINSER
|Cas-Br-M (murine) ecotropic retroviral transforming sequence|
|CBL (NP_005179, 736 a.a. ∽836 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26kDa.|
|Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|In ascites fluid|
|C-CBL, CBL2, RNF55|
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