CBL, Mouse, Clone: 6D12, Abnova™

Mouse monoclonal antibody raised against a partial recombinant CBL.

Manufacturer: Abnova Corporation H00000867M01C

Catalog No. 89-016-464

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    Formulation In ascites fluid
    Gene Accession No. NM_005188
    Gene Alias C-CBL, CBL2, RNF55
    Applications Enzyme Linked Immunosorbent Assay,Immunoprecipitation,Western Blotting
    Regulatory Status RUO
    Species Reactivity Human
    Gene ID (Entrez) 867
    Description Cas-Br-M (murine) ecotropic retroviral transforming sequence
    Gene CBL
    Gene Symbols CBL
    Storage Requirements Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
    Antigen CBL
    Format Liquid
    Host Species Mouse
    Immunogen CBL (NP_005179, 736 a.a. ∽836 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26kDa.
    Isotype IgG1, κ
    Quantity 200μL
    Primary or Secondary Primary
    Monoclonal or Polyclonal Monoclonal
    Clone 6D12
    Conjugate Unlabeled
    Cross Reactivity Human

    The cbl oncogene was first identified as part of a transforming retrovirus which induces mouse pre-B and pro-B cell lymphomas. As an adaptor protein for receptor protein-tyrosine kinases, it positively regulates receptor protein-tyrosine kinase ubiquitination in a manner dependent upon its variant SH2 and RING finger domains. Ubiquitination of receptor protein-tyrosine kinases terminates signaling by marking active receptors for degradation. [provided by RefSeq


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