Invitrogen™ CCDC141 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA521169

Catalog No. PIPA521169

Description

A suggested positive control is SK-N-SH cell lysate. PA5-21169 can be used with blocking peptide PEP-1283.

Coiled-coil domain-containing protein 141 (CCDC141), also known as CAMDI, is a recently identified disrupted in schizophrenia 1 (DISC1)-binding protein that also associates with myosin II. CCDC141 preferentially associates with phosphomyosin II and causes an accumulation of phosphomyosin II at the centrosome in a DISC1-dependent manner. Knockdown of CCDC141 expression by RNAi led to severely impaired radial migration with disoriented chromosomes, suggesting that CCDC141 is required for radial migration through DISC1 and myosin II-mediated centrosome positioning during neuronal development.

Specifications

• Antigen: CCDC141
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CCDC141
• Gene Alias: 2610301F02Rik; CAMDI; CCDC141; coiled-coil domain containing 141; coiled-coil domain-containing protein 141; Coiled-coil protein associated with myosin II and DISC1; ENSMUSG00000075261
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 285025, 545428
• Content And Storage: Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Immunohistochemistry, Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: Q6ZP82
• Gene Symbols: CCDC141
• Immunogen: An 18 amino acid peptide near the amino terminus of human CCDC141.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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