CCRL2 Rat anti-Mouse, PE, Clone: BZ2E3, BD
Rat Monoclonal Antibody
Manufacturer: BD Biosciences 564946
The BZ2E3 monoclonal antibody specifically binds to CCRL2 (C-C chemokine receptor-like 2) which is also known as Lipopolysaccharide-inducible C-C chemokine receptor (L-CCR/Lccr). CCRL2 is a chemokine receptor-like, 7-transmembrane protein that can bind CCL19 or the nonchemokine chemoattractant, chemerin/RARRES2. CCRL2 is expressed by a variety of cell types including mast cells, macrophages and some endothelial cells. CCRL2 appears to play various roles in regulating chemokine activities, e.g., by binding and internalizing excess local levels of the CCL19 /MIP-3β chemokine. Alternatively, endothelial cell-expressed CCRL2 can bind and present the chemerin/RARRES2 chemoattractant to lymphoid cells that express the functional signaling receptor, CMKLR1, and promote their adhesion.
|Aqueous buffered solution containing ≤0.09% sodium azide.|
|Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.|
|C-C chemokine receptor-like 2; L-CCR; Lccr; Cmkbr1l2; Ackr5|
|Mouse CCRL2 Peptide|
|The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.|
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