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CD102 Mouse anti-Human, APC, Clone: CBR-IC2/2, BD

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 564677

Catalog No. BDB564677

Item Discontinued This item has been discontinued by Fisher Scientific. Please to view product availability in your area.


Description

Description

The CBR-IC2/2 monoclonal antibody specifically binds to CD102 which is also known as, intercellular adhesion molecule-2 (ICAM-2/ICAM2). CD102 is a type I transmembrane glycoprotein, member of the immunoglobulin supergene family, with an approximate molecular weight of 55-65 kDa. Its extracellular domain consists of two C2-type immunoglobulin-like subunits. The transmembrane region is 26 residues in size and the intracellular region also has 26 residues. CD102 is expressed on vascular endothelial cells, lymphocytes, monocytes, eosinophils, and platelets, but not on resting neutrophils. It is a ligand for the leukocyte integrin CD11a/CD18, or leukocyte function-associated antigen-1 (LFA-1), and there are reports of CD102 binding to leukocyte integrin CD11b/CD18 (Mac-1). Antibody CBR-IC2/2 blocks the binding of CD102 to leukocyte integrin CD11a/CD18. CD102 plays an important role in lymphocyte recirculation and in providing costimulatory signals in the immune response.

TRUSTED_SUSTAINABILITY
Specifications

Specifications

CD102
Monoclonal
APC
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Human ICAM-2 Transfected Cell Line
50 Tests
Primary
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Flow Cytometry
CBR-IC2/2
ICAM2; ICAM-2; Intercellular adhesion molecule 2
Mouse
Affinity Purified
RUO
Human
IgG2a κ
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