Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Antibodies
  4. Primary Antibodies
  5. All Primary Antibodies
  6. CD104 Mouse anti-Human, Unlabeled, Clone: 7, BD

CD104 Mouse anti-Human, Unlabeled, Clone: 7, BD

Catalog No. BDB611232 Shop All BD Biosciences Products
Change view
Click to view available options
Quantity:
50 μg
1 product options available for selection
Product selection table with 1 available options. Use arrow keys to navigate and Enter or Space to select.
Catalog No. Quantity
BDB611232 50 μg
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 1 options available.
1 options
Catalog No. BDB611232 Supplier BD Biosciences Supplier No. 611232
Only null left
Add to Cart
Add to Cart

Description

Mouse Monoclonal Antibody

Cell adhesion to extracellular matrix components or to cell surface proteins, especially those expressed by leukocytes and endothelial cells, is mediated by integrins. Integrins contain noncovalently associated α and β subunits. At least 17 α and 8 β subunits have been identified and these proteins can heterodimerize to form 22 different receptors. The α6β4 integrin is a receptor for various laminins and binds with the highest affinity to laminins 4 and 5. It exhibits elevated expression in the basal cell layer of stratified epithelia, in Schwann cells at the onset of myelination, and in CD4-CD8- pre-T lymphocytes entering the thymus. In addition, α6β4 expression is increased in squamous carcinomas where it promotes invasion through a targeting of PI3 kinase activity. The majority of β4 comprises a cytoplasmic domain with unique signaling properties. The C-terminal portion of this domain contains two pairs of type III fibronectin-like motifs (FNIII) and a tyrosine activation motif (TAM). Additional domains in the cytoplasmic tail bind Shc and activate the MAPK pathway. Thus, integrin β4 is an integrin subunit that is important for cell survival, growth, and differentiation.

Host Species: Mouse
Clone: 7
Isotype: IgG1
Species Reactivity: Human
Immunogen: Human Integrin β4 aa. 1612-1821
Formula Weight [Chemical]: 200kDa

Immunofluorescence, Western Blotting

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD104
Applications Western Blot
Classification Monoclonal
Clone 7
Concentration 250μg/mL
Conjugate Unconjugated
Description Integrin β4
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Human Integrin β4 aa. 1612-1821
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Research Discipline Immunology
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at -20°C.
Isotype IgG1
Show More Show Less

Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov

For Research Use Only.

Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.