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CD105 (Endoglin) Mouse anti-Human, Unlabeled, Clone: 35, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 611315

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Catalog No. BDB611315


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Description

Description

Endoglin (CD105), a major glycoprotein of human vascular endothelium, is a type I integral membrane protein with a large extracellular region, a hydrophobic transmembrane region, and a short cytoplasmic tail. It also contains an RGD tripeptide that may be important for cellular adhesion. There are two forms of endoglin (S-endoglin and L-endoglin) that differ in the length of their cytoplasmic tails. However, the isoforms may have similar functional activity. When overexpressed in fibroblasts, both form disulfide-linked homodimers via their extracellular domains. Endoglin binds TGF-β1 and TGF-β3 by associating with TGF-β type II receptor and binds BMP-7 by associating with activin type II receptor. Thus, endoglin is an accessory protein of multiple TGF-β superfamily kinase receptor complexes. Loss of function mutations in the human endoglin gene cause hereditary hemorrhagic telangiectasia, which is characterized by vascular malformations. Deletion of endoglin in mice leads to death due to defective vascular development. Thus, endoglin is an endothelial specific cell surface protein that may regulate angiogenesis through interactions with TGF-β superfamily kinase receptors.

Host Species: Mouse
Clone: 35
Isotype: IgG1 κ
Species Reactivity: Human
Immunogen: Human S-Endoglin aa. 24-144
Formula Weight [Chemical]: 95kDa

Immunofluorescence, Western Blotting

Specifications

Specifications

CD105
35
Unconjugated
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Murine
IgG1, κ
RUO
Store undiluted at -20°C.
Monoclonal
Western Blot
250μg/mL
Endoglin
Affinity Purified
Human S-Endoglin aa. 24-144
150μg
Cell Biology
Primary
Human
Documents
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