CD105 Mouse anti-Human, FITC, Clone: MEM-226, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA119594
CD105 (Endoglin) is a homodimeric transmembrane glycoprotein serving in presence of TGFbetaR-2 as a receptor for TGFbeta-1 and TGFbeta-3. CD105 is highly expressed on endothelial cells and promotes angiogenesis during wound healing, infarcts and in a wide range of tumours and its gene expression is stimulated by hypoxia. CD105 prevents apoptosis in hypoxic endothelial cells and also antagonises the inhibitory effects of TGFbeta-1 on vascular endothelial cell growth and migration. Normal cellular levels of CD105 are required for formation of new blood vessels.
|PBS with 0.2% BSA and 15mM sodium azide|
|CD105, END, HHT1, ORW, ORW1, CD105 antigen, ENG|
|4° C, store in dark, DO NOT FREEZE!|
|Recombit vaccinia virus containing the human CD105 cDNA.|
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