CD106 Rat anti-Mouse, FITC, Clone: 429 (MVCAM.A), BD

Rat Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
BDB553332	BD Biosciences 553332	0.5 mg
BDB561678	BD Biosciences 561678	0.1 mg

Description

The 429 monoclonal antibody specifically binds to both the long (∼110 kDa) transmembrane-spanning form and the truncated (∼47 kDa) GPI-linked form of vascular cell adhesion molecule-1 (VCAM-1, CD106). CD106 is constitutively expressed on bone marrow stromal cells, myeloid cells, and splenic dendritic cells. Its expression on endothelial cells is upregulated by inflammatory cytokines and in certain pathologic conditions. CD106 expression has also been detected on apoptotic thymocytes, splenocytes, and lymphoid cell lines. VCAM-1 is a counter-receptor for VLA-4 ( α;4 β; 1 integrin) and LPAM-1 ( α;4 β; 7 integrin), and the 429 antibody partially blocks VCAM-1-mediated binding functions. Source of the immunogen was the mouse preadipose cell line PA6.

Specifications

• Antigen: CD106
• Concentration: 0.5mg/mL
• Classification: Monoclonal
• Host Species: Rat
• Research Discipline: Immunology
• Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
• Isotype: IgG2a κ
• Purification Method: Affinity Purified
• Description: Vcam-1; Vascular cell adhesion molecule 1; Vascular cell adhesion protein 1

• Clone: 429 (MVCAM.A)
• Applications: Flow Cytometry
• Conjugate: FITC
• Regulatory Status: RUO
• Target Species: Mouse
• Immunogen: Mouse preadipose cell line PA6
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

For Research Use Only.