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CD107b Rat anti-Mouse, PerCP-Cy5.5, Clone: M3/84, BD

Rat Monoclonal Antibody

Manufacturer:  BD Biosciences 564844

Catalog No. BDB564844

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The M3/84 monoclonal antibody specifically binds to CD107b which is also known as Mac-3, Lysosome-associated membrane protein 2 (LAMP-2/Lamp2/Lamp II), and Lysosomal membrane glycoprotein type B (LGP-B). CD107b is a single-pass type I transmembrane glycoprotein that constitutes a major integral membrane protein of lysosomes and may play a role in lysosomal function. CD107b is also expressed on the surface of mouse mononuclear phagocytes. Surface expression of the 92-110-kDa glycoprotein antigen increases during differentiation of monocytes to activated macrophages and may play a role in adhesion. The M3/84 mAb can detect CD107b antigen on tissue macrophages, thioglycollate-elicited peritoneal macrophages, and some myeloid cell lines, but not on lymphocytes or monocytes. In the bone marrow, very few cells display CD107b antigen on the surface, but a large proportion express cytoplasmic CD107b. The M3/84 antibody has also been reported to stain dendritic cells and endothelium in sections of thymus (both medulla and cortex), lymph nodes, spleen (white pulp), and gut-associated lymphoid tissue.



Aqueous buffered solution containing ≤0.09% sodium azide.
IgG1, κ
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Flow Cytometry
Mac-3; Lamp2; LAMP-2; Lysosome-associated membrane glycoprotein 2; LGP-B
Affinity Purified
Mouse C57Bl/6 peritoneal exudate cells
The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
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