CD117 Mouse anti-Human, APC, Clone: YB5.B8, BD

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 561118

Catalog No. BDB561118

Description

Recognizes CD117 (the C-Kit), a 145kDa cell-surface glycoprotein with tyrosine kinase activity. CD117 is present on hematopoietic progenitor cell subsets, thymocytes, mast cells, hepatocytes and histiocytes. CD117 serves as a cytokine receptor for steel factor (SLF), also known as stem cell factor (SCF) or mast cell growth factor (MGF). The interaction of c-kit and SLF is crucial to hematopoiesis, mast cell differentiation, melanogenesis, and germ cell development. The ability of YB5.B8 antibody to block the binding of c-kit ligand is still
controversial. This antibody is routinely tested by flow cytometric analysis. Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.

Host Species: Mouse
Clone: YB5.B8
Isotype: IgG1 κ
Species Reactivity: Human

Flow Cytometry

Specifications

• Antigen: CD117
• Classification: Monoclonal
• Concentration: 0.2mg/mL
• Description: KIT; c-Kit; SCFR; PBT; Mast/stem cell growth factor receptor
• Host Species: Mouse
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Target Species: Human
• Isotype: IgG1 κ

• Applications: Flow Cytometry
• Clone: YB5.B8
• Conjugate: APC
• Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
• Immunogen: Acute myelocytic leukemia blasts
• Quantity: 25 μg
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

For Research Use Only.