CD117 Mouse anti-Human, Brilliant Violet 421, Clone: YB5.B8, BD

Mouse Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
BDB562435	BD Biosciences 562435	25 Tests
BDB562434	BD Biosciences 562434	100 Tests

Description

The YB5.B8 monoclonal antibody specifically binds to CD117. CD117, also known as c-Kit, is a 145 kDa cell-surface glycoprotein with tyrosine kinase activity. CD117 is present on hematopoietic progenitor cell subsets, thymocytes, mast cells, hepatocytes and histiocytes.CD117 serves as a cytokine receptor for steel factor (SLF), also known as stem cell factor (SCF) or mast cell growth factor (MGF). The interaction of c-Kit and SLF is crucial to hematopoiesis, mast cell differentiation, melanogenesis, and germ cell development. The ability of
the YB5.B8 antibody to block the binding of c-Kit ligand is still controversial. The antibody was conjugated to Brilliant Violet 421 and has been developed in collaboration with Sirigen. With an Ex Max of 407-nm and Em Max at 421-nm, Brilliant Violet 421 can be excited by the violet laser and detected in the standard Pacific Blue filter set (eg, 450/50-nm filter). Brilliant Violet 421 conjugates are very bright, often exhibiting a 10 fold improvement in brightness compared to Pacific Blue conjugates.

Host Species: Mouse
Clone: YB5.B8
Isotype: IgG1, κ
Species Reactivity: Human

Flow Cytometry

Specifications

• Antigen: CD117
• Applications: Flow Cytometry
• Conjugate: Brilliant Violet 421
• Regulatory Status: RUO
• Formulation: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
• Isotype: IgG1 κ
• Purification Method: Affinity Purified
• Description: KIT; c-Kit; SCFR; PBT; Mast/stem cell growth factor receptor

• Clone: YB5.B8
• Classification: Monoclonal
• Host Species: Mouse
• Target Species: Human
• Immunogen: Acute myelocytic leukemia blasts
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

For Research Use Only.