CD119 Mouse anti-Human, Unlabeled, Clone: GIR-208, BD

Catalog No.	Quantity
BDB557531	0.25 mg

Catalog No. BDB557531 Supplier BD Biosciences Supplier No. 557531

Description

Mouse Monoclonal Antibody

The GIR-208 antibody recognizes the extracellular region of CD119 which is also known as the alpha chain subunit (80-95 kDa glycoprotein) of the human interferon-γ receptor (IFN-γRα). The functionally active-form of the human IFN-γ receptor consists of two (or more) subunits, with IFN-γRα responsible for IFN-γβ chains required for the transduction of biologic responses. The IFN-γ receptor α chain (CD119) is expressed on the surface of most human cells (except mature erythrocytes) including monocytes, macrophages, T cells, B cells, NK cells, neutrophils, fibroblasts, epithelial cells, and endothelium. Binding of 125I-labeled GIR-208 antibody to IFN-γRα+ cells is reported to be specifically inhibited in the presence of excess IFN-γ. GIR-208 does not cross react with IFN-γ as tested by ELISA. The ability of this antibody to bind to IFN-γ receptors of species other than human has not been determined. The immunogen used to generate this hybridoma was human IFN-γRα purified from human placenta. The GIR- 208 has been reported to block the binding of 125I-human IFN-γto IFN-γRα+ cells as well as purified, soluble human IFN-γRα. GIR-208 is a neutralizing antibody that has been shown to neutralize the anti-viral activity of IFN-γon WISH cells in a dose-dependent fashion.

Specifications

• Antigen: CD119
• Applications: ELISA
• Classification: Monoclonal
• Clone: GIR-208
• Concentration: 1.0mg/mL
• Conjugate: Unconjugated
• Description: IFN-γ Receptor α chain, IFNγRα
• Formulation: No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered. Endotoxin level is ≤0.01 EU/μg (≤0.001 ng/μg) of protein as determined by the LAL assay.
• Host Species: Mouse
• Immunogen: Human IFN-γRα
• Purification Method: Affinity Purified
• Quantity: 0.25 mg
• Regulatory Status: RUO
• Research Discipline: Immunology
• Primary or Secondary: Primary
• Target Species: Human
• Content And Storage: Store undiluted at 4°C
• Isotype: IgG1 κ

For Research Use Only.