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CD119 Mouse anti-Human, PE, Clone: GIR-208, BD

Catalog No. BDB558934 Shop All BD Biosciences Products
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BDB558934 0.2 mg
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Catalog No. BDB558934 Supplier BD Biosciences Supplier No. 558934
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Description

Mouse Monoclonal Antibody

The GIR-208 antibody recognizes the extracellular region of CD119 which is also known as the alpha chain subunit (80-95 kDa glycoprotein) of the human interferon- γreceptor (IFN- γR α ). The functionally active-form of the human IFN- γreceptor consists of two (or more) subunits, with IFN- γR α responsible for IFN- γβ chains required for the transduction of biologic responses. The IFN- γreceptor α chain (CD119) is expressed on the surface of most human cells (except mature erythrocytes) including monocytes, macrophages, T cells, B cells, NK cells, neutrophils, fibroblasts, epithelial cells, and endothelium. Binding of 125I-labeled GIR-208 antibody to IFN- γR α + cells is reported to be specifically inhibited in the presence of excess IFN- γ. GIR-208 does not cross react with IFN- γas tested by ELISA. The ability of this antibody to bind to IFN- γreceptors of species other than human has not been determined. The immunogen used to generate this hybridoma was human IFN- γR α purified from human placenta. The GIR- 208 has been reported to block the binding of 125I-human IFN-γto IFN-γRα+ cells as well as purified, soluble human IFN-γRα. GIR-208 is a neutralizing antibody that has been shown to neutralize the anti-viral activity of IFN-γon WISH cells in a dose-dependent fashion.

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD119
Applications Flow Cytometry
Classification Monoclonal
Clone GIR-208
Concentration 0.2mg/mL
Conjugate PE
Description IFN-γ Receptor α chain, IFNγRα
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Mouse
Immunogen Human IFN-γRα
Purification Method Affinity Purified
Quantity 0.2 mg
Regulatory Status RUO
Research Discipline Immunology
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG1 κ
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