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  6. CD11a Mouse anti-Human, Unlabeled, Clone: 27, BD

CD11a Mouse anti-Human, Unlabeled, Clone: 27, BD

Catalog No. BDB610826 Shop All BD Biosciences Products
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BDB610826 50 μg
BDB610827 150 μg
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Catalog No. BDB610826 Supplier BD Biosciences Supplier No. 610826

Description

Mouse Monoclonal Antibody

CD11a, also known as integrin αL or LFA-1 (lymphocyte function-associated antigen-1), is a member of the β2 family of integrins that includes Mac-1 and p150,95. It is composed of two noncovalently linked α and β chains which are associated with the actin cytoskeleton. CD11a (integrin αL) has been reported to be expressed on the surface of T cells, neutrophils, and macrophages. It is involved in cell-cell adhesion and it also conveys signals from the plasma membrane to the cytoplasm. Activation of the TCR/CD3 complex on T cells transmits intracellular signals that activate integrin αL (“inside-out” signaling). This results in the conformational change of integrin αL, which increases its affinity for its ligand ICAM-1,-2, and -3. Furthermore, this signaling releases integrin αL from the actin cytoskeleton, resulting in clustering of this surface molecule. The high affinity conformation and the clustering of integrin αL increases the adhesion between it and ICAM. This adhesion is essential for leukocyte activation and results in “outside-in” signaling which induces the polymerization of actin, thereby stabilizing the integrin αL-ICAM interaction. This interaction is necessary for CTL and NK mediated killing, T and B cell responses, ADCC, and immune cell extravasation.

Immunofluorescence, Immunoprecipitation, Western Blotting

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD11a
Applications Western Blot
Classification Monoclonal
Clone 27
Concentration 250μg/mL
Conjugate Unconjugated
Description Integrin αL; LFA-1α
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Human LFA-1α aa. 64-199
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Research Discipline Immunology
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at -20°C.
Isotype IgG1 κ
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For Research Use Only.

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