CD11a Mouse anti-Human, Unlabeled, Clone: 27, BD

Catalog No.	Quantity
BDB610827	150 μg
BDB610826	50 μg

Catalog No. BDB610827 Supplier BD Biosciences Supplier No. 610827

Description

Mouse Monoclonal Antibody

CD11a, also known as integrin αL or LFA-1 (lymphocyte function-associated antigen-1), is a member of the β2 family of integrins that includes Mac-1 and p150,95. It is composed of two noncovalently linked α and β chains which are associated with the actin cytoskeleton. CD11a (integrin αL) has been reported to be expressed on the surface of T cells, neutrophils, and macrophages. It is involved in cell-cell adhesion and it also conveys signals from the plasma membrane to the cytoplasm. Activation of the TCR/CD3 complex on T cells transmits intracellular signals that activate integrin αL (“inside-out” signaling). This results in the conformational change of integrin αL, which increases its affinity for its ligand ICAM-1,-2, and -3. Furthermore, this signaling releases integrin αL from the actin cytoskeleton, resulting in clustering of this surface molecule. The high affinity conformation and the clustering of integrin αL increases the adhesion between it and ICAM. This adhesion is essential for leukocyte activation and results in “outside-in” signaling which induces the polymerization of actin, thereby stabilizing the integrin αL-ICAM interaction. This interaction is necessary for CTL and NK mediated killing, T and B cell responses, ADCC, and immune cell extravasation.

Immunofluorescence, Immunoprecipitation, Western Blotting

Specifications

• Antigen: CD11a
• Applications: Immunofluorescence, Western Blot
• Classification: Monoclonal
• Clone: 27
• Concentration: 250μg/mL
• Conjugate: Unconjugated
• Host Species: Mouse
• Immunogen: Human LFA-1α aa. 64-199
• Purification Method: Affinity Purified
• Quantity: 150 μg
• Regulatory Status: RUO
• Research Discipline: Immunology
• Primary or Secondary: Primary
• Target Species: Human
• Isotype: IgG1

For Research Use Only.