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CD11a Rat anti-Mouse, Unlabeled, Clone: M17/4, BD

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Description

Rat Monoclonal Antibody

The M17/4 antibody reacts with the 180 kDa α; L chain of LFA-1 (CD11a/CD18, α; L β; 2 integrin), a heterodimeric surface glycoprotein expressed on almost all leukocytes. CD8a+CD8b- intestinal intraepithelial T lymphocytes, which are believed to be thymus independent, do not express CD11a. LFA-1 mediates a variety of heterotypic and homotypic intercellular adhesions through interaction with ICAM-1 (CD54) and ICAM-2 (CD102), including participation in the immunological synapses between CD8+ T lymphocytes and antigen-presenting cells. mAb M17/4 blocks a variety of LFA-1-mediated cells interactions in vitro, and costimulatory effects have also been described. In vivo treatment with M17/4 mAb reduces the severity of graft-versus-host reactions, prolongs allograft survival, inhibits the development of autoimmunity, and blocks substance P-induced leukocyte migration. The M17/4 and 2D7 (Cat. No. 553120) antibodies are reported to recognize different epitopes of the CD11a molecule.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD11a
Applications Flow Cytometry
Classification Monoclonal
Clone M17/4
Concentration 31.25μg/mL
Conjugate Unconjugated
Description Itgal; Integrin alpha-L; Integrin αL; ITAL; LFA-1A; LFA-1α; Ly-15
Formulation Aqueous buffered solution containing BSA, goat serum, and ≤0.09% sodium azide.
Host Species Rat
Immunogen C57BL/6 Mouse Splenic Secondary Cytotoxic T Lymphocytes
Purification Method Affinity Purified
Quantity 1 mL
Regulatory Status RUO
Research Discipline Immunology
Primary or Secondary Primary
Target Species Mouse
Content And Storage Store undiluted at 4°C
Isotype IgG2a κ
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Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov

For Research Use Only.

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