CD11a Mouse anti-Rat, Unlabeled, Clone: WT.1, BD

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 559979

Catalog No. BDB559979

Description

The WT.5 antibody reacts with the asubunit of LFA-1 (αLβ2 integrin, CD11a/CD18), a heterodimeric surface glycoprotein which is found on the majority of leukocytes, but not on peritoneal macrophages or peritoneal mast cells. LFA-1 mediates a variety of heterotypic and homotypic intercellular adhesions through interaction with ICAM-1 (CD54) and ICAM-2 (CD102). WT.1 mAb recognizes both the activated and unactivated forms of LFA-1. It inhibits the binding of LFA-1 to ICAM-1 in several in vitro assays, including binding of Concanavalin A-stimulated lymphocytes (Con A blasts) to purified ICAM-1 and Mg2+-dependent aggregation of concanavalin A-stimulated blasts. It has also been reported to inhibit leukocyte infiltration in several in vivo models of inflammation.

Specifications

• Antigen: CD11a
• Classification: Monoclonal
• Concentration: 0.5mg/mL
• Description: Integrin αL chain, LFA-1 α chain
• Host Species: Mouse
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Target Species: Rat
• Isotype: IgG2a κ

• Applications: Flow Cytometry
• Clone: WT.1
• Conjugate: Unconjugated
• Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
• Immunogen: PHA-stimulated rat splenocytes and rat thymic lymphoma FTL-43
• Quantity: 0.1 mg
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C