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CD11b Mouse anti-Human, Alexa Fluor 488, Clone: ICRF44 (also known as 44), BD

Catalog No. BDB561687 Shop All BD Biosciences Products
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BDB561687 25 Tests
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Catalog No. BDB561687 Supplier BD Biosciences Supplier No. 561687
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Description

Mouse Monoclonal Antibody

The ICRF44 monoclonal antibody specifically binds to CD11b, the 165-kDa adhesion glycoprotein that associates with the 95-kDa integrin β2 (CD18) to form the CD11b/CD18 complex, also known as Mac-1 or CR3. CD11b is expressed on activated lymphocytes, monocytes, granulocytes, and a subset of NK cells. CD11b functions in cell-cell and cell-substrate interactions and is a receptor for iC3b, CD54 (ICAM-1), CD102 (ICAM-2) and CD50 (ICAM-3). This antibody significantly inhibits polymorphonuclear leukocyte aggregation in response to fMLP.

This antibody is routinely tested by flow cytometric analysis. Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD11b
Applications Flow Cytometry
Classification Monoclonal
Clone ICRF44 (also known as 44)
Conjugate Alexa Fluor 488
Description Mac-1α, integrin αM subunit, CR3 α chain
Formulation Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Human monocytes
Purification Method Affinity Purified
Quantity 25 Tests
Regulatory Status RUO
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG1 κ
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