Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

MilliporeSigma™ anti-CD11b FITC, Clone: M1/70,

Rat Monoclonal Antibody

Manufacturer:  MilliporeSigma™ MABF802

 View more versions of this product

Catalog No. MABF802MI


Add to cart

Description

Description

Specifically detects CD11b Clone: M1/70 in Human, Mouse samples, and it is validated for Flow Cytometry

The M1/70 antibody reacts with human and mouse CD11b, also known as integrin alpha M. This 165-170kDa cell surface glycoprotein is part of a family of integrin receptors that mediate adhesion between cells (cell-cell) and components of the extracellular matrix, e.g. fibrinogen (cell-matrix). In addition, integrins are active signaling receptors which recruit leukocytes to inflammatory sites and promote cell activation. Complete, functional integrin receptors consist of distinct combinations of integrin chains which are differentially expressed. Integrin alphaM (CD11b) assembles with Integrin beta-2 (CD18) into a receptor known as Macrophage Antigen-1 (Mac-1) or complement receptor type 3 (CR3). This receptor binds and induces intracellular signaling through ICAM-1 on endothelial cells and can also facilitate removal of iC3b bearing foreign cells.The M1/70 antibody is widely used as a marker for CD11b expression on mouse macrophages, granulocytes, neutrophils, and NK cells. The antibody is also reported to be cross-reactive for Rhesus macaque CD11b.
Specifications

Specifications

CD11b
M1/70
Purified Rat monoclonal containing 10mM NaH2PO4, 150mM NaCl, 0.09% NaN3, 0.1% gelatin, pH 7.2.
Purified
Rat
IgG2b, κ
500μg
Inflammation, Immunology
Primary
Human, Murine
Flow Cytometry
FITC
P05555
Itgam
Proprietary immunogen
Purified by size-exclusion chromatography
RUO
2°C to 8°C undiluted for one year from date of shipment protected from light; Do not freeze
Monoclonal
SDS
Documents
Product Certifications
Promotions

Promotions

Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit

For Research Use Only