CD11b/Mac-1 Mouse anti-Human, BUV395, Clone: ICRF44 (also known as 44), BD

Mouse Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
BDB563840	BD Biosciences 563840	25 Tests
BDB563839	BD Biosciences 563839	100 Tests

Description

The ICRF44 monoclonal antibody specifically binds to CD11b, the 165-kDa adhesion glycoprotein that associates with the 95-kDa integrin β 2 (CD18) to form the CD11b/CD18 complex, also known as Mac-1 or CR3. CD11b is expressed on activated lymphocytes, monocytes, granulocytes, and a subset of NK cells. CD11b functions in cell-cell and cell-substrate interactions and is a receptor for iC3b, CD54 (ICAM-1), CD102 (ICAM-2) and CD50 (ICAM-3). This antibody significantly inhibits polymorphonuclear leukocyte aggregation in response to fMLP.

The antibody was conjugated to BD Horizon™ BUV395 which has been exclusively developed by BD Biosciences as an optimal dye for use on a 355nm laser equipped instrument. With an Ex Max at 348nm and an Em Max at 395nm, this dye has virtually no spillover into any other detector. BD Horizon™ BUV395 can be excited with a 355nm laser and detected with a 379/28 filter.

Specifications

• Antigen: CD11b
• Applications: Flow Cytometry
• Conjugate: Brilliant Ultraviolet 395
• Regulatory Status: RUO
• Formulation: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
• Isotype: IgG1 κ
• Purification Method: Affinity Purified
• Description: Mac-1α, integrin αM subunit, CR3 α chain

• Clone: ICRF44 (also known as 44)
• Classification: Monoclonal
• Host Species: Mouse
• Target Species: Human
• Immunogen: Human monocytes
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

For Research Use Only.