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MilliporeSigma™ anti-CD11c Red Fluor 710, Clone: N418,

Catalog No. MABF1501MI Shop All MilliporeSigma Products
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MABF1501MI 25 μg
MABF1502MI 100 μg
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Description

Armenian Hamster Monoclonal Antibody

Specifically detects CD11c Clone: N418 in Mouse samples, and it is validated for Flow Cytometry

The N418 antibody reacts with mouse CD11c, also known as integrin alpha X. This 150kDa cell surface glycoprotein is part of a family of integrin receptors that mediate adhesion between cells (cell-cell) and components of the extracellular matrix, e.g. fibrinogen (cell-matrix). In addition, integrins are active signaling receptors which recruit leukocytes to inflammatory sites and promote cell activation. Complete, functional integrin receptors consist of distinct combinations of integrin chains which are differentially expressed. Integrin alpha X (CD11c) assembles with Integrin beta-2 (CD18) into a receptor complex known as CR4 which can bind and induce signaling through ICAMs and VCAM-1 on endothelial cells and can also facilitate removal of iC3b bearing foreign cells.The N418 antibody is widely used as a marker for CD11c expression on dendritic cells (DC), often in parallel with markers for CD11b, for identification of developmental stages and mature subsets of this cell type. CD11c is prominently expressed on tissue macrophages, and is also detected on some types of activated T cells and intestinal intraepithelial lymphocytes (IEL).
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD11c
Applications Flow Cytometry
Classification Monoclonal
Clone N418
Conjugate Red Fluor 710
Formulation Purified Armenian Hamster monoclonal containing 10mM NaH2PO4, 150mM NaCl, 0.09% NaN3, 0.1% gelatin, pH 7.2.
Gene Accession No. Q9QXH4
Gene Symbols Itgax
Host Species Armenian Hamster
Immunogen Proprietary immunogen
Purification Method Purified by size-exclusion chromatography
Quantity 25 μg
Regulatory Status RUO
Research Discipline Inflammation, Immunology
Primary or Secondary Primary
Target Species Mouse
Content And Storage 2°C to 8°C undiluted for one year from date of shipment protected from light; Do not freeze
Form Purified
Isotype IgG
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For Research Use Only

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