CD120a Hamster anti-Mouse, Unlabeled, Clone: 55R-286, BD

Catalog No.	Quantity
BDB559915	0.5 mg

Catalog No. BDB559915 Supplier BD Biosciences Supplier No. 559915

Description

Hamster Monoclonal Antibody

The 55R-286 antibody reacts with the extracellular region of the 55 kDa receptor for the mouse cytokines, Tumor Necrosis Factor (TNF) and lymphotoxin- α (LT- α). This receptor, referred to as the p55 or Type I Tumor Necrosis Factor Receptor (TNFRI) [aka, CD120a], is expressed by a variety of cell lines and normal cell types including T cells, monocytes, macrophages, and neutrophils. B cells express very low or undetectable levels of TNFRI whereas mature erythrocytes are uniformly negative for TNFRI expression. In addition, the 55R-286 antibody can bind to a soluble, truncated form of the mouse Type I TNFR that is shed by cells in response to certain stimuli, e.g., cells treated with LPS or TNF. The in vivo administration of nonblocking, nonagonistic 55R-286 antibody reportedly results in the linear accumulation of shed, soluble forms of the TNFRI in the circulation. The 55R-286 antibody does not recognize the 75 kD (p75) Type II TNFR (aka, CD120b). 55R-286 does not block the binding and does not neutralize the bioactivity of the TNF ligand on L929 target cell populations that express TNFRI. The immunogen used to generate the 55R-286 hybridoma was a purified, soluble extracellular domain of the mouse TNFRI.

Specifications

• Antigen: CD120a
• Applications: Flow Cytometry
• Classification: Monoclonal
• Clone: 55R-286
• Concentration: 0.5mg/mL
• Conjugate: Unconjugated
• Description: TNF Receptor, Type I/p55
• Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
• Host Species: Hamster
• Immunogen: Mouse TNFRI
• Purification Method: Affinity Purified
• Quantity: 0.5 mg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Mouse
• Content And Storage: Store undiluted at 4°C
• Isotype: IgG1 κ