CD120b Armenian Hamster anti-Mouse, Brilliant Violet 421, Clone: TR75-89, BD
Armenian Hamster Monoclonal Antibody
Manufacturer: BD Biosciences 564088
The TR75-89 monoclonal antibody specifically binds to the extracellular region of CD120b, the 75 kDa receptor for the mouse cytokines, tumor necrosis factor (TNF, aka TNF- α ) and lymphotoxin-alpha (LT- α , aka lymphotoxin, TNF- β ). This receptor, referred to as the p75 or Type II Tumor Necrosis Factor Receptor (TNFRII), or TNFRSF1B, is expressed by a variety of cell lines and normal cell types including T cells, monocytes, macrophages, and neutrophils. Resting B cells express low or undetectable levels of TNFRII whereas mature erythrocytes are uniformly negative for TNFRII expression. In addition, the TR75-89 antibody can bind to a soluble, truncated form of the mouse Type II TNFR that is shed by cells in response to certain stimuli, e.g., cells treated with LPS or TNF. The in vivo administration of nonblocking, nonagonistic TR75-89 antibody reportedly results in the linear accumulation of shed, soluble forms of p75 TNFR in the circulation. The TR75-89 antibody does not recognize the 55 kDa (p55) Type I TNFR (aka, CD120a). TR75-89 does not block the binding and does not neutralize the bioactivity of the TNF ligand on L929 target cell populations that express p75 (and p55) TNFR. The immunogen used to generate the TR75-89 hybridoma was a purified, soluble extracellular domain of the mouse Type II TNFR.
|Brilliant Violet 421|
|Aqueous buffered solution containing BSA and ≤0.09% sodium azide.|
|Tnfrsf1b; Tnfr2; TNF-R2; TNFR p75; TNFRII; TNF-R-II; TNFBR|
|Mouse Type II TNFR|
|Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.|
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