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CD121b Rat anti-Mouse, Brilliant Violet 421, Clone: 4E2, BD

Catalog No. BDB562926 Shop All BD Biosciences Products
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BDB562926 50 μg
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Catalog No. BDB562926 Supplier BD Biosciences Supplier No. 562926
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Description

Rat Monoclonal Antibody

The 4E2 monoclonal antibody specifically binds to CD121b which is also known as the IL-1 receptor type II (IL-1RII, IL-1R2) or IL-1 receptor beta (IL-1R-beta, IL-1Rβ). CD121b is encoded by the Il1r2 gene and presents as a 68 kDa type I transmembrane glycoprotein. It is expressed on a variety of cell types including B cells, neutrophils, monocytes, and bone marrow progenitor cells. A soluble form of CD121b is produced by proteolysis especially after cellular activation. Unlike the IL-1 type I receptor (CD121a), CD121b has a short cytoplasmic domain and does not mediate IL-1 signaling. CD121b may function in a membrane or soluble form as a decoy receptor that can bind IL-1 and reduce its effective concentration and biological activity. The 4E2 antibody blocks IL-1 binding to the IL-1 receptor type II.

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD121b
Applications Flow Cytometry
Classification Monoclonal
Clone 4.00E+02
Concentration 0.2mg/mL
Conjugate Brilliant Violet 421
Description Il1r2; IL-1RII; IL-1R2; Il1rb; IL-1Rβ; IL-1R-beta; IL-1 receptor beta chain
Formulation Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Host Species Rat
Immunogen Mouse IL-1RII Protein
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Mouse
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG2a κ
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