CD122 Rat anti-Mouse, Alexa Fluor 647, Clone: 5H4, BD
Rat Monoclonal Antibody
Manufacturer: BD Biosciences 564924
The 5H4 antibody monoclonal antibody specifically binds to mouse CD122. CD122 is a 70-85 kDa type I transmembrane glycoprotein of the hematopoietin receptor superfamily. CD122 is also known as IL-2 Receptor beta chain (IL-2R β ) or IL-15 Receptor beta chain (IL-15R β ) as it helps form signaling receptor complexes for Interleukin-2 (IL-2) or IL-15, respectively. CD122 can combine with either CD132 (γc) alone or CD132 plus CD25 (IL-2Rα) to form inte rmediate or high-affinity IL-2 Receptor complexes, respectively. The IL-2R β chain is constitutively expressed on NK cells and at lower levels on some thymocytes, T cells, B cells, monocytes, and macrophages. IL-2R β chain expression is up regulated by IL-2. The immunogen used to generate this hybridoma was rat myel oma cells transfected with a truncated IL-2R β cDNA. 5H4 does not block IL-2 binding to the IL-2 Receptor.
|Alexa Fluor 647|
|Aqueous buffered solution containing ≤0.09% sodium azide|
|Il2rb; Il-2Rbeta; IL-2Rβ; IL-15Rbeta; IL-2/15 Receptor-beta; IL-2/15Rbeta|
|Rat myeloma cells transfected with a truncated IL-2R β cDNA|
|Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.|
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