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CD123 Rat anti-Mouse, Biotin, Clone: 5B11, BD

Catalog No. BDB555070 Shop All BD Biosciences Products
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BDB555070 0.5 mg
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Catalog No. BDB555070 Supplier BD Biosciences Supplier No. 555070
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Description

Rat Monoclonal Antibody

The 5B11 monoclonal antibody specifically recognizes mouse CD123, the α chain subunit (IL-3R α ) of the mouse IL-3 receptor. The IL-3R α chain is a 60-70 kD transmembrane glycoprotein that binds IL-3 with low affinity but cannot transduce signals by itself. The mouse IL-3R α chain can complex with either of two homologous β chain subunits ( β c and β α subunits of the mouse IL-3R, IL-5R and GM-CSFR to form high-affinity receptors. The β IL-3 subunit can form high affinity IL-3 receptor complexes with only the IL-3R α subunit. The β IL-3 subunit clone is specific for mouse IL-3 and binds with low affinity. The immunogen used to generate the 5B11 hybridoma was CTLL cells transfected with the mouse IL-3R alpha chain. The 5B11 antibody does not block the binding of IL-3 protein to the high affinity IL-3 receptor heterodimer.

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD123
Applications Flow Cytometry
Classification Monoclonal
Clone 5B11
Concentration 0.5mg/mL
Conjugate Biotin
Description Il3ra; IL-3RA; IL-3R-alpha; IL-3 Receptor alpha; IL-3 Receptor α; SUT-1
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Rat
Immunogen Mouse IL-3R transfected CTLL cells
Purification Method Affinity Purified
Quantity 0.5 mg
Regulatory Status RUO
Research Discipline Immunology
Primary or Secondary Primary
Target Species Mouse
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG2a κ
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For Research Use Only.

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