CD123 Rat anti-Mouse, Biotin, Clone: 5B11, BD

Rat Monoclonal Antibody

Supplier:  BD Biosciences 555070

Catalog No. BDB555070

Description

The 5B11 monoclonal antibody specifically recognizes mouse CD123, the α chain subunit (IL-3R α ) of the mouse IL-3 receptor. The IL-3R α chain is a 60-70 kD transmembrane glycoprotein that binds IL-3 with low affinity but cannot transduce signals by itself. The mouse IL-3R α chain can complex with either of two homologous β chain subunits ( β c and β α subunits of the mouse IL-3R, IL-5R and GM-CSFR to form high-affinity receptors. The β IL-3 subunit can form high affinity IL-3 receptor complexes with only the IL-3R α subunit. The β IL-3 subunit clone is specific for mouse IL-3 and binds with low affinity. The immunogen used to generate the 5B11 hybridoma was CTLL cells transfected with the mouse IL-3R alpha chain. The 5B11 antibody does not block the binding of IL-3 protein to the high affinity IL-3 receptor heterodimer.

Specifications

• Antigen: CD123
• Classification: Monoclonal
• Concentration: 0.5mg/mL
• Description: Il3ra; IL-3RA; IL-3R-alpha; IL-3 Receptor alpha; IL-3 Receptor α; SUT-1
• Host Species: Rat
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

• Applications: Flow Cytometry
• Clone: 5B11
• Conjugate: Biotin
• Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
• Immunogen: Mouse IL-3R transfected CTLL cells
• Quantity: 0.5 mg
• Research Discipline: Immunology
• Target Species: Mouse
• Isotype: IgG2a κ

For Research Use Only.