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CD123 Mouse anti-Human, PerCP-Cy5.5, Clone: 7G3, BD

Catalog No. BDB558714 Shop All BD Biosciences Products
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Description

Mouse Monoclonal Antibody

Reacts with human CD123, the 70 kD IL-3 receptor α chain (IL-3Rα), which associates with the 120-140kDa β subunit. The β chain is shared with the receptors for interleukins IL-5 and GM-CSF. IL-3Rα is expressed on hematopoietic progenitors. This antibody has been reported to block the binding of 125I-IL-3 to high and low affinity IL-3 receptors. In functional experiments, this antibody was found to inhibit acute myeloid leukemia cell proliferation, basophil histamine release, endothelial cell-mediated IL-8 secretion, and neutrophil transmigration. This antibody has been reported to be useful for immunoprecipitation, western blot and immunofluorescent staining for flow cytometry. IL-3Rα plays an important role in hematopoietic progenitor cell growth and differentiation. At the Fifth HLDA Workshop, the human IL-3 receptor was designated CD123.

Flow Cytometry

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD123
Applications Flow Cytometry
Classification Monoclonal
Clone 7G3
Conjugate PerCP-Cyanine5.5
Description IL3RA; IL-3RA; IL-3Rα; IL-3R-alpha; Interleukin-3 receptor subunit alpha
Formulation Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Human IL-3Ra-transfected cells
Quantity 100 Tests
Regulatory Status RUO
Research Discipline Immunology
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG2a κ
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For Research Use Only.

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