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CD124 Rat anti-Mouse, Unlabeled, Clone: MIL4R-M2, BD

Catalog No. BDB552952 Shop All BD Biosciences Products
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BDB552952 0.5 mg
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Catalog No. BDB552952 Supplier BD Biosciences Supplier No. 552952

Description

Rat Monoclonal Antibody

The mIL4R-M2 monoclonal antibody specifically binds to the α subunit of the mouse Interleukin-4 Receptor (IL-4R α , aka, CD124). The mIL4R-M2 antibody does not recognize human or rat IL-4R; crossreactivities with IL-4R from other species have not been established. The mouse IL-4R α is a 140 kDa transmembrane glycoprotein that is expressed by B and T lymphocytes and a variety of other hematopoietic and nonhematopoietic cells and cell lines. The cell surface IL-4R α chain binds IL-4 with high affinity and associates with either the common γchain (IL-4R α / γα (sIL-4R) that result either from enzymatic cleavage of the cell surface extracellular IL-4R α domain or from differential mRNA splicing and secretion by cells. These sIL-4R retain their high-affinity ligand binding domain and appear to either enhance or inhibit IL-4-mediated functions depending on the relative local levels of IL-4 and sIL-4R. The immunogen used to generate the mIL4R-M2 hybridoma was CTLL-19.4 cells, a subclone of CTLL-2 cells that express high levels of IL-4R α .

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD124
Applications ELISA
Classification Monoclonal
Clone MIL4R-M2
Concentration 0.5mg/mL
Conjugate Unconjugated
Description IL-4 Receptor α chain
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Rat
Immunogen CTLL-19.4 cells
Purification Method Affinity Purified
Quantity 0.5 mg
Regulatory Status RUO
Research Discipline Immunology
Primary or Secondary Primary
Target Species Mouse
Content And Storage Store undiluted at 4°C
Isotype IgG2a κ
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For Research Use Only.

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