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CD127 Rat anti-Mouse, Biotin, Clone: B12-1, BD

Catalog No. BDB555288 Shop All BD Biosciences Products
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BDB555288 0.5 mg
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Catalog No. BDB555288 Supplier BD Biosciences Supplier No. 555288
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Description

Rat Monoclonal Antibody

The B12-1 monoclonal antibody specifically binds to mouse CD127 which is also known as, the Interleukin-7 Receptor alpha chain ( IL-7Rα ). CD127 associates with CD132 ( common γchain ) to form a high-affinity signaling IL-7R complex that mediates the biological effects of IL-7. CD127 can also complex with the Thymic Stromal Lymphopoietin Receptor (TSLPR) subunit to bind and mediate cellular responses to TSLP. CD127 is a 65-75 kDa type-I transmembrane protein that belongs to the hematopoietin receptor and the Ig gene superfamilies. Mice lacking CD127 display profoundly impaired development of the B and T lymphoid cell lineages, but display no obvious non lymphoid abnormalities. IL-7Rα is expressed on common lymphoi with low-density γδ TCR expression upregulate CD127 expression in response to IL-2, which may be secreted by ne ighboring αβ TCR+ T cells.

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD127
Applications Flow Cytometry
Classification Monoclonal
Clone B12-1
Concentration 0.5mg/mL
Conjugate Biotin
Description Interleukin-7 receptor alpha chain; IL-7R alpha; IL7RA;IL-7RA; IL-7Rα; Il7r
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Rat
Immunogen Mouse CD127-human IgG fusion protein
Purification Method Affinity Purified
Quantity 0.5 mg
Regulatory Status RUO
Research Discipline Immunology
Primary or Secondary Primary
Target Species Mouse
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG2a λ
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For Research Use Only.

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