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CD137 Mouse anti-Human, Unlabeled, Clone: H41BB-M127, BD

Catalog No. BDB552532 Shop All BD Biosciences Products
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BDB552532 0.5 mg
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Catalog No. BDB552532 Supplier BD Biosciences Supplier No. 552532
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Description

Mouse Monoclonal Antibody

Human 4-1BB, also known as CDw137, is a type I transmembrane glycoprotein belonging to the tumor necrosis factor receptor (TNFR) superfamily. Naοve T cells lack the 4-1BB, which is not only induced upon T cell activation, but also remains on activated T cells. It has been reported that the expression of 4-1BB is restricted to primed CD4+ and CD8+ cells. When triggered by either 4-1BB ligand or antibody ligation, the 4-1BB molecule can act as a co-stimulator to induce T-cell activation and proliferation. In recent studies, 4-1BB has been emphasized for its effect on the development and survival of functionally active effector CD8 (+) T cells against tumors, virus infections, allogenic immune responses, and for potential therapeutic application.

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD137
Applications ELISA
Classification Monoclonal
Clone H41BB-M127
Concentration 0.5mg/mL
Conjugate Unconjugated
Description 4-1BB, CDw137
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Mouse
Purification Method Affinity Purified
Quantity 0.5 mg
Regulatory Status RUO
Research Discipline Immunology
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at 4°C
Isotype IgG1 κ
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For Research Use Only.

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