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CD138 Rat anti-Mouse, APC, Clone: 281-2, BD

Catalog No. BDB558626 Shop All BD Biosciences Products
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25 μg
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BDB558626 0.1 mg
BDB561705 25 μg
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Catalog No. BDB558626 Supplier BD Biosciences Supplier No. 558626
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Description

Rat Monoclonal Antibody

The 281-2 antibody reacts with the core protein of CD138 (Syndecan-1), a cell-surface, integral membrane heparan sulfate- and chondroitin sulfate-containing proteoglycan that binds to interstitial extracellular matrix molecules. Syndecan-1 is predominantly expressed on epithelial cells, where its expression correlates with normal epithelial organization. It is also expressed on B lymphocytes at specific stages during their differentiation: precursor B cells in the bone marrow and antibody-secreting cells, including plasma cells, but not mature peripheral B cells. It is thus implicated in mediating B cell-matrix interactions. CD138 expression is also regulated during embryonic development, and the molecule shows a tissue- specific structural polymorphism resulting from different post-translational modifications. The 281-2 antibody may be used to detect the differently glycosylated forms, because it reacts with the core protein. Furthermore, the mAb detects the Syndecan-1 ectodomain which is cleaved from cell surfaces by a metalloproteinase.

Flow Cytometry

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD138
Applications Flow Cytometry
Classification Monoclonal
Clone 281-2
Concentration 0.2mg/mL
Conjugate APC
Description SYND1; Syndecan-1; syn-1; Sdc1; Sstn; synstatin
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Rat
Immunogen NAMRU mouse mammary gland epithelial cell line NMuMG
Purification Method Affinity Purified
Quantity 0.1 mg
Regulatory Status RUO
Research Discipline Immunology
Primary or Secondary Primary
Target Species Mouse
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG2a κ
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For Research Use Only.

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