CD140a Rat anti-Mouse, Unlabeled, Clone: APA5, BD

Rat Monoclonal Antibody

Supplier:  BD Biosciences 558774

Catalog No. BDB558774

Description

The APA5 antibody monoclonal antibody specifically binds to CD140a, the Platelet-Derived Growth Factor Receptor alpha chain (PDGFR-a, PDGFR-α). CD140a is a receptor tyrosine kinase that is widely expressed on cells of mesenchymal origin in the embryo and adult. CD140a is expressed on several other cell types during embryonic development, but not on hematopoietic cells. CD140a binds to PDGF A and B chains, in contrast to PDGFR-b (CD140b) that binds only to the PDGF B chain. Biologically active PDGF is a disulphide-linked dimer, forming the AA, AB, and BB isoforms. Ligand binding to the PDGF Receptor induces the formation of receptor dimers (aa, ab, or bb), autophosphorylation, and internalization. The APA5 antibody has been demonstrated to block binding ofPDGF-AA to PDGFR-a-expressing cells in vitroand to block some PDGF-mediated developmental events in vivo.

Specifications

• Antigen: CD140a
• Classification: Monoclonal
• Concentration: 0.5mg/mL
• Description: Pdgfra; Pdgfr2; PDGF-R alpha; Platelet derived growth factor receptor alpha
• Host Species: Rat
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C

• Applications: Flow Cytometry
• Clone: APA5
• Conjugate: Unconjugated
• Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
• Immunogen: Mouse PDGF Receptor α chain
• Quantity: 0.1 mg
• Research Discipline: Immunology
• Target Species: Mouse
• Isotype: IgG2a κ